Quantification of myocardial blood flow by CZT-SPECT with motion correction and comparison with ¹⁵O-water PET.

ABSTRACT:

Background

We compared quantification of MBF and myocardial flow reserve (MFR) with a 99mTc-sestamibi CZT-SPECT to ¹⁵O-water PET.

Methods

SPECT MBF for thirty patients in the WATERDAY study was re-analyzed by QPET software with motion correction and optimal placement of the arterial input function. ¹⁵O-water PET MBF was re-quantified using dedicated software. Inter-operator variability was assessed using repeatability coefficients (RPC).

Results

Significant correlations were observed between global (r = 0.91, P < 0.001) and regional MBF (r = 0.86, P < 0.001) with SPECT compared to PET. Global MBF (rest 0.95 vs 1.05 ml/min/g, P = 0.07; stress 2.62 vs 2.68 mL/min/g, P = 0.17) and MFR (2.65 vs 2.75, P = 0.86) were similar between SPECT and PET. Rest

SUBMITTER: Otaki Y 

PROVIDER: S-EPMC7042031 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature