Transplantation of PEGylated islets enhances therapeutic efficacy in a diabetic nonhuman primate model.

ABSTRACT: Islet cell transplantation can lead to insulin independence, reduced hypoglycemia, and amelioration of diabetes complications in patients with type 1 diabetes. The systemic delivery of anti-inflammatory agents, while considered crucial to limit the early loss of islets associated with intrahepatic infusion, increases the burden of immunosuppression. In an effort to decrease the pharmaceutical load to the patient, we modified the pancreatic islet surface with long-chain poly(ethylene glycol) (PEG) to mitigate detrimental host-implant interactions. The effect of PEGylation on islet engraftment and long-term survival was examined in a robust nonhuman primate model via three paired transplants of dosages 4300, 8300, and 10 000 islet equivalents per kg body weight. A reduced immunosuppressive r

SUBMITTER: Stabler CL 

PROVIDER: S-EPMC7042048 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature