Donor-Recipient Relationship and Risk of ESKD in Live Kidney Donors of Varied Racial Groups.

ABSTRACT:

Rationale & objective

Risk factors for kidney failure are the basis of live kidney donor candidate evaluation. We quantified risk for end-stage kidney disease (ESKD) by the biological relationship of the donor to the recipient, a risk factor that is not addressed by current clinical practice guidelines.

Study design

Retrospective cohort study.

Setting & participants

A cohort of 143,750 US kidney donors between 1987 and 2017.

Exposure

Biological relationship of donor and recipient.

Outcome

ESKD. Donors' records were linked to national dialysis and transplantation registries to ascertain development of the outcome.

Analytic approach

Donors were observed over a median of 12 (interquartile range, 6-18; maximum, 30) years. Survival analysis methods tha

SUBMITTER: Muzaale AD 

PROVIDER: S-EPMC7042071 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature