Blockade of angiotensin AT₁ receptors prevents arterial remodelling and stiffening in iron-overloaded rats.

ABSTRACT:

Background and purpose

Damage to the vasculature caused by chronic iron-overload in both humans and animal models, is characterized by endothelial dysfunction and reduced compliance. In vitro, blockade of the angiotensin II AT₁ receptors reversed functional vascular changes induced by chronic iron-overload. In this study, the effect of chronic AT₁ receptor blockade on aorta stiffening was assessed in iron-overloaded rats.

Experimental approach

Male Wistar rats were treated for 15 days with saline as control group, iron dextran 200 mg·kg^-1 ·day^-1 , 5 days a week (iron-overload group), losartan (20 mg·kg^-1 ·day^-1 in drinking water), and iron dextran plus losartan. Mechanical properties of the aorta were assessed

SUBMITTER: Fidelis HG 

PROVIDER: S-EPMC7042103 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature