Mu and delta opioid receptors play opposite nociceptive and behavioural roles on nerve-injured mice.

ABSTRACT:

Background and purpose

Mu and delta opioid receptors(MOP, DOP) contribution to the manifestations of pathological pain is not understood. We used genetic approaches to investigate the opioid mechanisms modulating neuropathic pain and its comorbid manifestations.

Experimental approach

We generated conditional knockout mice with MOP or DOP deletion in sensoryNav1.8-positive neurons (Nav1.8), in GABAergic forebrain neurons (DLX5/6) orconstitutively (CMV). Mutant mice and wild-type littermates were subjected topartial sciatic nerve ligation (PSNL) or sham surgery and their nociception wascompared. Anxiety-, depressivelike behaviour and cognitive performance were also measured. Opioid receptor mRNA expression, microgliosis and astrocytosis were assessed in the dorsalroot ganglia

SUBMITTER: Martinez-Navarro M 

PROVIDER: S-EPMC7042108 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature