Prenatal and postnatal alcohol exposure increases vulnerability to cocaine addiction in adult mice.

ABSTRACT:

Background and purpose

Alcohol exposure in utero may lead to a wide range of long-lasting morphological and behavioural deficiencies known as fetal alcohol spectrum disorders (FASD), associated with a higher risk of later developing neuropsychiatric disorders. However, little is known about the long-term consequences of cocaine use and abuse in individuals with FASD. This study aimed to investigate the effects of maternal binge alcohol drinking during prenatal and postnatal periods on cocaine reward-related behaviours in adult offspring.

Experimental approach

Pregnant C57BL/6 female mice were exposed to an experimental protocol of binge alcohol consumption (drinking-in-the-dark test) from gestation to weaning. Male offspring were subsequently left undisturbed until reaching

SUBMITTER: Cantacorps L 

PROVIDER: S-EPMC7042116 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature