Preferential HLA-B27 Allorecognition Displayed by Multiple Cross-Reactive Antiviral CD8⁺ T Cell Receptors.

ABSTRACT: T cells provide essential immunosurveillance to combat and eliminate infection from pathogens, yet these cells can also induce unwanted immune responses via T cell receptor (TCR) cross-reactivity, also known as heterologous immunity. Indeed, pathogen-induced TCR cross-reactivity has shown to be a common, robust, and functionally potent mechanism that can trigger a spectrum of human immunopathologies associated with either transplant rejection, drug allergy, and autoimmunity. Here, we report that several virus-specific CD8⁺ T cells directed against peptides derived from chronic viruses (EBV, CMV, and HIV-1) presented by high frequency HLA-A and -B allomorphs differentially cross-react toward HLA-B27 allotypes in a highly focused and hierarchical manner. Given the commonality of c

SUBMITTER: Rowntree LC 

PROVIDER: S-EPMC7042382 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature