Enhanced drug loading efficiency of contact lenses via salt-induced modulation.

ABSTRACT: Low drug loading efficiency is one of the main obstacles hindering the application of contact lenses (CLs) as the carrier for extended ocular drug delivery. Here in this study, a simple and effective drug loading method based on salt induced modulation was proposed and demonstrated with mechanism elucidation. First of all, using poly (2-hydroxyethyl methacrylate) (p-HEMA) as the contact lens material, betaxolol hydrochloride, Diclofenac Sodium and Betaxolol Base as the model drugs with different solubility, influence of salt concentration, salt type (sodium salts of sulfate, chloride, and sulfocyanate) and drug properties in the loading solution on drug loading efficiency was investigated. Mechanism of enhanced drug loading in contact lens was further explored via studying the influence of

SUBMITTER: Zhu Q 

PROVIDER: S-EPMC7042482 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature