Mix and (mis-)match - The mechanosensing machinery in the changing environment of the developing, healthy adult and diseased heart.

ABSTRACT: The composition and the stiffness of cardiac microenvironment change during development and/or in heart disease. Cardiomyocytes (CMs) and their progenitors sense these changes, which decides over the cell fate and can trigger CM (progenitor) proliferation, differentiation, de-differentiation or death. The field of mechanobiology has seen a constant increase in output that also includes a wealth of new studies specific to cardiac or cardiomyocyte mechanosensing. As a result, mechanosensing and transduction in the heart is increasingly being recognised as a main driver of regulating the heart formation and function. Recent work has for instance focused on measuring the molecular, physical and mechanical changes of the cellular environment - as well as intracellular contributors to the passiv

SUBMITTER: Ward M 

PROVIDER: S-EPMC7042712 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature