Association of Monogenic vs Polygenic Hypercholesterolemia With Risk of Atherosclerotic Cardiovascular Disease.

ABSTRACT:

Importance

Monogenic familial hypercholesterolemia (FH) is associated with lifelong elevations in low-density lipoprotein cholesterol (LDL-C) levels and increased risk of atherosclerotic cardiovascular disease (CVD). However, many individuals with hypercholesterolemia have a polygenic rather than a monogenic cause for their condition. It is unclear if a genetic variant for hypercholesterolemia alters the risk of CVD.

Objectives

To assess whether a genetic variant for hypercholesterolemia alters the risk of atherosclerotic CVD and to evaluate how this risk compares with that of nongenetic hypercholesterolemia.

Design, setting, and participants

In this genetic-association, case-control, cohort study, individuals aged 40 to 69 years were recruited by the UK Biobank from

SUBMITTER: Trinder M 

PROVIDER: S-EPMC7042820 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature