Temporal Dynamics of Cortical Microinfarcts in Cerebral Small Vessel Disease.

ABSTRACT:

Importance

Neuropathology studies show a high prevalence of cortical microinfarcts (CMIs) in aging individuals, especially in patients with cerebrovascular disease and dementia. However, most, are invisible on T1- and T2-weighted magnetic resonance imaging (MRI), raising the question of how to explain this mismatch. Studies on small acute infarcts, detected on diffusion-weighted imaging (DWI), suggest that infarcts are largest in their acute phase and reduce in size thereafter. Therefore, we hypothesized that a subset of the CMI that are invisible on MRI can be detected on MRI in their acute phase. However, to our knowledge, a serial imaging study investigating the temporal dynamics of acute CMI (A-CMI) is lacking.

Objective

To determine the prevalence of chronic CMI (C-CMI)

SUBMITTER: Ter Telgte A 

PROVIDER: S-EPMC7042834 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature