Predictive Accuracy of a Polygenic Risk Score Compared With a Clinical Risk Score for Incident Coronary Heart Disease.

ABSTRACT:

Importance

Polygenic risk scores comprising millions of single-nucleotide polymorphisms (SNPs) could be useful for population-wide coronary heart disease (CHD) screening.

Objective

To determine whether a polygenic risk score improves prediction of CHD compared with a guideline-recommended clinical risk equation.

Design, setting, and participants

A retrospective cohort study of the predictive accuracy of a previously validated polygenic risk score was assessed among 4847 adults of white European ancestry, aged 45 through 79 years, participating in the Atherosclerosis Risk in Communities (ARIC) study and 2390 participating in the Multi-Ethnic Study of Atherosclerosis (MESA) from 1996 through December 31, 2015, the final day of follow-up. The performance of the polygenic

SUBMITTER: Mosley JD 

PROVIDER: S-EPMC7042849 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature