Tolerability of Antiseizure Medications in Individuals With Newly Diagnosed Epilepsy.

ABSTRACT:

Importance

Tolerability is a key determinant of the effectiveness of epilepsy treatment. It is important to evaluate whether the overall tolerability has improved.

Objective

To identify factors associated with poor tolerability of antiseizure medications (ASMs) and examine temporal changes in tolerability.

Design, setting, and participants

This was a longitudinal cohort study at a specialist clinic in Glasgow, Scotland. Patients with newly diagnosed and treated epilepsy between July 1982 and October 2012 were included from 2282 eligible individuals. They were followed up until April 2016 or death. Data analysis was completed in August 2019.

Exposures

Antiseizure medications.

Main outcomes and measures

Univariable and multivariable survival analyses were

SUBMITTER: Alsfouk BAA 

PROVIDER: S-EPMC7042855 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature