Trends in Incidence of Early-Onset Colorectal Cancer in the United States Among Those Approaching Screening Age.

ABSTRACT:

Importance

Early-onset colorectal cancer incidence rates among patients aged 45 to 49 years have been considered much lower compared with the rates among patients aged 50 to 54 years, prompting debate about earlier screening benefits at 45 years. However, the observed incidence rates in the Surveillance, Epidemiology, and End Results (SEER) registries may underestimate colorectal cancer case burdens in those younger than 50 years compared with those older than 50 years because average-risk screening is generally not performed to detect preclinical cases of colorectal cancer. Finding steep incidence increases of invasive stage (beyond in situ) cases of colorectal cancer from age 49 to 50 years would be consistent with high rates of preexisting, undetected cancers in younger patients

SUBMITTER: Abualkhair WH 

PROVIDER: S-EPMC7042874 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature