Association of a Reproducible Epigenetic Risk Profile for Schizophrenia With Brain Methylation and Function.

ABSTRACT:

Importance

Schizophrenia is a severe mental disorder in which epigenetic mechanisms may contribute to illness risk. Epigenetic profiles can be derived from blood cells, but to our knowledge, it is unknown whether these predict established brain alterations associated with schizophrenia.

Objective

To identify an epigenetic signature (quantified as polymethylation score [PMS]) of schizophrenia using machine learning applied to genome-wide blood DNA-methylation data; evaluate whether differences in blood-derived PMS are mirrored in data from postmortem brain samples; test whether the PMS is associated with alterations of dorsolateral prefrontal cortex hippocampal (DLPFC-HC) connectivity during working memory in healthy controls (HC); explore the association between interactions

SUBMITTER: Chen J 

PROVIDER: S-EPMC7042900 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature