Effect of High-Dose vs Standard-Dose Vitamin D Supplementation in Pregnancy on Bone Mineralization in Offspring Until Age 6 Years: A Prespecified Secondary Analysis of a Double-Blinded, Randomized Clinical Trial.

ABSTRACT:

Importance

Studies suggest an association between maternal vitamin D status during pregnancy and offspring anthropometry and bone mineralization, but investigations are few and with mixed results.

Objective

To investigate the effect of a high dose vs standard dose of vitamin D supplementation in pregnancy on anthropometric and bone outcomes until age 6 years in the offspring.

Design, setting, and participants

A prespecified analysis of a double-blinded, randomized clinical trial in the Copenhagen Prospective Studies on Asthma in Childhood 2010 mother-child cohort that included 623 pregnant mothers and their 584 children. Data were analyzed between January 2019 and September 2019.

Interventions

Vitamin D supplementation of 2800 IU/d (high-dose) vs 400 IU/d (stan

SUBMITTER: Brustad N 

PROVIDER: S-EPMC7042912 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature