Effect of Hydrocortisone vs Pasireotide on Pancreatic Surgery Complications in Patients With High Risk of Pancreatic Fistula: A Randomized Clinical Trial.

ABSTRACT:

Importance

Both hydrocortisone and pasireotide have been shown in randomized clinical trials to be effective in reducing postoperative complications of pancreatic surgery, but to date no randomized clinical trial has evaluated the effectiveness of pasireotide compared with hydrocortisone.

Objective

To assess the noninferiority of hydrocortisone compared with pasireotide in reducing complications after partial pancreatectomy.

Design, setting, and participants

A noninferiority, parallel-group, individually randomized clinical trial was conducted at a single academic center between May 19, 2016, and December 17, 2018. Outcome collectors and analyzers were blinded. A total of 281 patients undergoing partial pancreatectomy were assessed for inclusion. Patients younger than

SUBMITTER: Tarvainen T 

PROVIDER: S-EPMC7042940 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature