Active Antioxidizing Particles for On-Demand Pressure-Driven Molecular Release.

ABSTRACT: Overproduced reactive oxygen species (ROS) are closely related to various health problems including inflammation, infection, and cancer. Abnormally high ROS levels can cause serious oxidative damage to biomolecules, cells, and tissues. A series of nano- or microsized particles has been developed to reduce the oxidative stress level by delivering antioxidant drugs. However, most systems are often plagued by slow molecular discharge, driven by diffusion. Herein, this study demonstrates the polymeric particles whose internal pressure can increase upon exposure to H₂O₂, one of the ROS, and in turn, discharge antioxidants actively. The on-demand pressurized particles are assembled by simultaneously encapsulating water-dispersible manganese oxide (MnO₂) nanosheet

SUBMITTER: Seo Y 

PROVIDER: S-EPMC7042956 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature