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Response-adapted intensification with cyclophosphamide, bortezomib, and dexamethasone versus no intensification in patients with newly diagnosed multiple myeloma (Myeloma XI): a multicentre, open-label, randomised, phase 3 trial.

ABSTRACT:

SUBMITTER: Jackson GH

PROVIDER: S-EPMC7043012 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Response-adapted intensification with cyclophosphamide, bortezomib, and dexamethasone versus no intensification in patients with newly diagnosed multiple myeloma (Myeloma XI): a multicentre, open-label, randomised, phase 3 trial.

Jackson Graham H GH Davies Faith E FE Pawlyn Charlotte C Cairns David A DA Striha Alina A Collett Corinne C Waterhouse Anna A Jones John R JR Kishore Bhuvan B Garg Mamta M Williams Cathy D CD Karunanithi Kamaraj K Lindsay Jindriska J Wilson Jamie N JN Jenner Matthew W MW Cook Gordon G Kaiser Martin F MF Drayson Mark T MT Owen Roger G RG Russell Nigel H NH Gregory Walter M WM Morgan Gareth J GJ

The Lancet. Haematology 20191014 12

<h4>Background</h4>Multiple myeloma has been shown to have substantial clonal heterogeneity, suggesting that agents with different mechanisms of action might be required to induce deep responses and improve outcomes. Such agents could be given in combination or in sequence on the basis of previous response. We aimed to assess the clinical value of maximising responses by using therapeutic agents with different modes of action, the use of which is directed by the response to the initial combinati ...[more]

PMID: 31624047

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