Oral typhoid vaccine Ty21a elicits antigen-specific resident memory CD4⁺ T cells in the human terminal ileum lamina propria and epithelial compartments.

ABSTRACT:

Background

Salmonella enterica serovar Typhi (S. Typhi) is a highly invasive bacterium that infects the human intestinal mucosa and causes ~ 11.9-20.6 million infections and ~ 130,000-223,000 deaths annually worldwide. Oral typhoid vaccine Ty21a confers a moderate level of long-lived protection (5-7 years) in the field. New and improved vaccines against enteric pathogens are needed but their development is hindered by a lack of the immunological correlates of protection especially at the site of infection. Tissue resident memory T (T_RM) cells provide immediate adaptive effector immune responsiveness at the infection site. However, the mechanism(s) by which S. Typhi induces T_RM in the intestinal mucosa are unknown. Here, we focus on the induction of S. Typhi-sp

SUBMITTER: Booth JS 

PROVIDER: S-EPMC7043047 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature