Drug-associated valvular heart diseases and serotonin-related pathways: a meta-analysis.

ABSTRACT:

Objective

Serotonergic appetite suppressants and ergot-derived dopamine agonists have been associated with drug-induced valvular heart disease. The purpose of this meta-analysis is to synthesise the current evidence of a link between several medications affecting sertonergic pathways and valvular heart disease.

Methods

PubMed was searched to identify studies evaluating an association between medications with serotonergic activity and cardiac valvular pathology. Case reports, uncontrolled studies and in vitro studies were excluded. Relevant studies were assessed for quality and potential bias; those of adequate quality were included in a quantitative synthesis. Sensitivity analyses were conducted, and potential publication bias was examined.

Results

There was a consist

SUBMITTER: Fortier JH 

PROVIDER: S-EPMC7043398 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature