Plasma CD36 and Incident Diabetes: A Case-Cohort Study in Danish Men and Women.

ABSTRACT:

Background

Membrane CD36 is a fatty acid transporter implicated in the pathogenesis of metabolic disease. We aimed to evaluate the association between plasma CD36 levels and diabetes risk and to examine if the association was independent of adiposity among Danish population.

Methods

We conducted a case-cohort study nested within the Danish Diet, Cancer and Health study among participants free of cardiovascular disease, diabetes and cancer and with blood samples and anthropometric measurements (height, weight, waist circumference, and body fat percentage) at baseline (1993 to 1997). CD36 levels were measured in 647 incident diabetes cases that occurred before December 2011 and a total of 3,515 case-cohort participants (236 cases overlap).

Results

Higher plasma CD36 lev

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7043971 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature