Cytochrome c phosphorylation: Control of mitochondrial electron transport chain flux and apoptosis.

ABSTRACT: Cytochrome c (Cytc)¹is a cellular life and death decision molecule that regulates cellular energy supply and apoptosis through tissue specific post-translational modifications. Cytc is an electron carrier in the mitochondrial electron transport chain (ETC) and thus central for aerobic energy production. Under conditions of cellular stress, Cytc release from the mitochondria is a committing step for apoptosis, leading to apoptosome formation, caspase activation, and cell death. Recently, Cytc was shown to be a target of cellular signaling pathways that regulate the functions of Cytc by tissue-specific phosphorylations. So far five phosphorylation sites of Cytc have been mapped and functionally characterized, Tyr97, Tyr48, Thr28, Ser47, and Thr58. All five phosphorylations partial

SUBMITTER: Kalpage HA 

PROVIDER: S-EPMC7044036 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature