Type I IFN ineffectively activates neonatal dendritic cells limiting respiratory antiviral T-cell responses.

ABSTRACT: Insufficient T-cell responses contribute to the increased burden of viral respiratory disease in infancy. Neonatal dendritic cells (DCs) often provide defective activation of pathogen-specific T cells through mechanisms that are incompletely understood, which hinders vaccine design for this vulnerable age group. Enhancing our characterization of neonatal DC sub-specialization and function is therefore critical to developing their potential for immunomodulation of T-cell responses. In this study, we engineered respiratory syncytial virus (RSV) to express a model protein, ovalbumin, to track antigen-presenting DCs in vivo. We found that murine neonatal conventional DC1s (cDC1s) efficiently migrated and presented RSV-derived antigen, challenging the paradigm that neonatal DCs are globally imm

SUBMITTER: Lau-Kilby AW 

PROVIDER: S-EPMC7044048 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature