Associations of annual ambient PM_2.5 components with DNAm PhenoAge acceleration in elderly men: The Normative Aging Study.

ABSTRACT: Current studies indicate that long-term exposure to ambient fine particulate matter (PM_2.5) is related with global mortality, yet no studies have explored relationships of PM_2.5 and its species with DNAm PhenoAge acceleration (DNAmPhenoAccel), a new epigenetic biomarker of phenotypic age. We identified which PM_2.5 species had association with DNAmPhenoAccel in a one-year exposure window in a longitudinal cohort. We collected whole blood samples from 683 elderly men in the Normative Aging Study between 1999 and 2013 (n = 1254 visits). DNAm PhenoAge was calculated using 513 CpGs retrieved from the Illumina Infinium HumanMethylation450 BeadChip. Daily concentrations of PM_2.5 species were measured at a fixed air-quality monitoring site and one-year m

SUBMITTER: Wang C 

PROVIDER: S-EPMC7044052 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature