Structural and Functional Alterations in the Contralesional Medial Temporal Lobe in Glioma Patients.

ABSTRACT:

Background

The human brain has an extraordinary ability to functionally change or reorganize its structure in response to disease. The aim of this study is to assess the structural and functional plasticity of contralesional medial temporal lobe (MTL) in patients with unilateral MTL glioma.

Methods

Sixty-eight patients with unilateral MTL glioma (left MTL glioma, n = 33; right MTL glioma, n = 35) and 40 healthy controls were recruited and scanned with 3D T1 MRI and rest-fMRI. We explored the structure of the contralesional MTL using voxel-based morphometry (VBM) and assessed the memory networks of the contralesional hemisphere using resting-state functional connectivity (rs-FC). The association between FC and cognitive function was assessed with partial correla

SUBMITTER: Yuan T 

PROVIDER: S-EPMC7044242 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature