Notch signalling regulates epibranchial placode patterning and segregation.

ABSTRACT: Epibranchial placodes are the geniculate, petrosal and nodose placodes that generate parts of cranial nerves VII, IX and X, respectively. How the three spatially separated placodes are derived from the common posterior placodal area is poorly understood. Here, we reveal that the broad posterior placode area is first patterned into a Vgll2⁺/Irx5⁺ rostral domain and a Sox2⁺/Fgf3⁺/Etv5⁺ caudal domain relative to the first pharyngeal cleft. This initial rostral and caudal patterning is then sequentially repeated along each pharyngeal cleft for each epibranchial placode. The caudal domains give rise to the neuronal and non-neuronal cells in the placode, whereas the rostral domains are previously unrecognized structures, servin

SUBMITTER: Wang L 

PROVIDER: S-EPMC7044445 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature