Loss of Crb2b-lf leads to anterior segment defects in old zebrafish.

ABSTRACT: Defects in the retina or the anterior segment of the eye lead to compromised vision and affect millions of people. Understanding how these ocular structures develop and are maintained is therefore of paramount importance. The maintenance of proper vision depends, among other factors, on the function of genes controlling apico-basal polarity. In fact, mutations in polarity genes are linked to retinal degeneration in several species, including human. Here we describe a novel zebrafish crb2b allele (crb2be40 ), which specifically affects the crb2b long isoform. crb2be40 mutants are viable and display normal ocular development. However, old crb2be40 mutant fish develop multiple defects in structures of the anterior segment, which includes the cornea, the iris and the lens. Phenotypes are chara

SUBMITTER: Kujawski S 

PROVIDER: S-EPMC7044448 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature