Dataset Information

HERG1 and HIF-2α Behave as Biomarkers of Positive Response to Bevacizumab in Metastatic Colorectal Cancer Patients.

ABSTRACT:

Background

In search of novel biomarkers of response to bevacizumab in metastatic colorectal cancer (mCRC), we analyzed the expression and prognostic role of several proteins related to angiogenesis.

Methods

A retrospective, multicenter study on 80 surgical samples from mCRC patients treated in first line with bevacizumab plus chemotherapy was accomplished. The following proteins were analyzed by immunohistochemistry: hERG1 potassium channel, β1-integrin, pAKT, NFkB, HIF-1α, HIF-2α, p53, VEGF-A, GLUT-1, and CA-IX. Data were analyzed in conjunction with the clinicopathological characteristics of the patients, KRAS status, response to bevacizumab, and follow-up.

Results

(1) All the proteins were expressed in the samples, with statistically significant associations between HIF-1α and gender, HIF-2α and left colon, hERG1 and VEGF-A, β1-integrin and HIF-2α, GLUT-1 and both HIF-1α and HIF-2α, and CA-IX and VEGF-A. (2) At the univariate analysis, positivity for hERG1, VEGF-A, and the active form of HIF-2α (aHIF-2α), and the G3 histological grade showed a positive impact on progression-free survival (PFS). (3) hERG1 and aHIF-2α maintained their positive impact on PFS at the multivariate analysis. (4) hERG1 behaved as a protective factor for PFS independently on KRAS status.

Conclusions

hERG1 and aHIF-2α might help to identify patients who would benefit from bevacizumab treatment.

SUBMITTER: Iorio J

PROVIDER: S-EPMC7044526 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Publications

hERG1 and HIF-2α Behave as Biomarkers of Positive Response to Bevacizumab in Metastatic Colorectal Cancer Patients.

Iorio Jessica J Lastraioli Elena E Tofani Lorenzo L Petroni Giulia G Antonuzzo Lorenzo L Messerini Luca L Perrone Giuseppe G Caputo Damiano D Francesconi Maria M Amato Maria Michelina MM Cadei Moris M Arcangeli Giuseppina G Villanacci Vincenzo V Boni Luca L Coppola Roberto R Di Costanzo Francesco F Arcangeli Annarosa A

Translational oncology 20200225 3

<h4>Background</h4>In search of novel biomarkers of response to bevacizumab in metastatic colorectal cancer (mCRC), we analyzed the expression and prognostic role of several proteins related to angiogenesis.<h4>Methods</h4>A retrospective, multicenter study on 80 surgical samples from mCRC patients treated in first line with bevacizumab plus chemotherapy was accomplished. The following proteins were analyzed by immunohistochemistry: hERG1 potassium channel, β1-integrin, pAKT, NFkB, HIF-1α, HIF-2 ...[more]

PMID: 32105990

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