United States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts.

ABSTRACT: As part of the United States Pharmacopeia's ongoing review of dietary supplement safety data, a new comprehensive systematic review on green tea extracts (GTE) has been completed. GTEs may contain hepatotoxic solvent residues, pesticide residues, pyrrolizidine alkaloids and elemental impurities, but no evidence of their involvement in GTE-induced liver injury was found during this review. GTE catechin profiles vary significantly with manufacturing processes. Animal and human data indicate that repeated oral administration of bolus doses of GTE during fasting significantly increases bioavailability of catechins, specifically EGCG, possibly involving saturation of first-pass elimination mechanisms. Toxicological studies show a hepatocellular pattern of liver injury. Published adverse event c

SUBMITTER: Oketch-Rabah HA 

PROVIDER: S-EPMC7044683 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature