Development and validation of risk stratification trees for incident slow gait speed in persons at high risk for knee osteoarthritis.

ABSTRACT: OBJECTIVES:Disability prevention strategies are more achievable before osteoarthritis disease drives impairment. It is critical to identify high-risk groups, for strategy implementation and trial eligibility. An established measure, gait speed is associated with disability and mortality. We sought to develop and validate risk stratification trees for incident slow gait in persons at high risk for knee osteoarthritis, feasible in community and clinical settings. METHODS:Osteoarthritis Initiative (derivation cohort) and Multicenter Osteoarthritis Study (validation cohort) participants at high risk for knee osteoarthritis were included. Outcome was incident slow gait over up to 10-year follow-up. Derivation cohort classification and regression tree analysis identified predictors from easily a

SUBMITTER: Sharma L 

PROVIDER: S-EPMC7044716 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature