Parametric methods for [¹⁸F]flortaucipir PET.

ABSTRACT: [¹⁸F]Flortaucipir is a PET tau tracer used to visualize tau binding in Alzheimer's disease (AD) in vivo. The present study evaluated the performance of several methods to obtain parametric images of [¹⁸F]flortaucipir. One hundred and thirty minutes dynamic PET scans were performed in 10 AD patients and 10 controls. Parametric images were generated using different linearization and basis function approaches. Regional binding potential (BP_ND) and volume of distribution (V_T) values obtained from the parametric images were compared with corresponding values derived using the reversible two-tissue compartment model (2T4k_V_B). Performance of SUVr parametric images was assessed by comparing values with distribution volume ratio (DVR) and SRTM

SUBMITTER: Golla SS 

PROVIDER: S-EPMC7044757 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature