Trial protocol: preoperative administration of tranexamic acid in sleeve gastrectomy (PATAS) to reduce haemorrhage rates. A randomised controlled trial.

ABSTRACT:

Introduction

Fast-track protocols often include short-term thromboprophylaxis and short length of hospital stay. These treatment strategies may negatively affect the occurrence and diagnosis of postoperative haemorrhage. Over the years, the rates of venous thromboembolic events (VTEs) have decreased, while there seems to be an increase in the occurrence of postoperative haemorrhage. Tranexamic acid (TXA) can potentially lower the incidence of postoperative haemorrhage. This trial aims to investigate whether preoperative administration of TXA reduces the preoperative and postoperative haemorrhage rates in laparoscopic sleeve gastrectomy (LSG).

Methods and analysis

This is a single centre double-blind randomised placebo-controlled trial. Patients undergoing an LSG are included

SUBMITTER: Leeman M 

PROVIDER: S-EPMC7044819 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature