A double-blind randomised placebo-controlled trial of melatonin as an adjuvant agent in induction of labour (MILO): a study protocol.

ABSTRACT:

Introduction

Induction of labour (IOL) is a common practice. In Australia, up to 40% of women undergoing labour induction will ultimately have a caesarean section. As a biological role for melatonin in the onset and progress of labour has been demonstrated, we aim to test the hypothesis that addition of melatonin will reduce the need for caesarean section.

Methods and analysis

This is a double-blind, randomised, placebo-controlled trial in women undergoing IOL at term. We plan to randomise 722 women (1:1 ratio) to receive either melatonin (four doses of 10 mg melatonin: first dose-in the evening at the time of cervical balloon or Dinoprostone PGE₂ vaginal pessary insertion, second dose-at time of oxytocin infusion commencement, third dose-6 hours after the second

SUBMITTER: Swarnamani K 

PROVIDER: S-EPMC7044825 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature