Cholinesterase alterations in delirium after cardiosurgery: a German monocentric prospective study.

ABSTRACT:

Objectives

Postoperative delirium (POD) is a common complication after elective cardiac surgery. Recent evidence indicates that a disruption in the normal activity of the cholinergic system may be associated with delirium.

Design

Prospective observational study.

Setting

Single-centre at a European academic hospital.

Primary and secondary outcome measures

In our study the enzyme activities of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) were determined preoperatively as well as on the first and second postoperative day. The confusion assessment method for the intensive care unit was used to screen patients for the presence of POD.

Results

A total of 114 patients were included in the study. POD was associated with a decrease in BChE activit

SUBMITTER: Adam EH 

PROVIDER: S-EPMC7044931 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature