Aspirin and fracture risk: a systematic review and exploratory meta-analysis of observational studies.

ABSTRACT:

Objectives

This review provides insights into the potential for aspirin to preserve bone mineral density (BMD) and reduce fracture risk, building knowledge of the risk-benefit profile of aspirin.

Methods

We conducted a systematic review and exploratory meta-analysis of observational studies. Electronic searches of MEDLINE and Embase, and a manual search of bibliographies was undertaken for studies published to 28 March 2018. Studies were included if: participants were men or women aged ≥18 years; the exposure of interest was aspirin; and relative risks, ORs and 95% CIs for the risk of fracture or difference (percentage or absolute) in BMD (measured by dual energy X-ray absorptiometry) between aspirin users and non-users were presented. Risk of bias was assessed using the Joa

SUBMITTER: Barker AL 

PROVIDER: S-EPMC7044955 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature