Safety of inadvertent administration of live zoster vaccine to immunosuppressed individuals in a UK-based observational cohort analysis.

ABSTRACT:

Objectives

To investigate the safety of live attenuated varicella zoster vaccination when administered to immunosuppressed individuals.

Design

Prospective observational cohort study.

Setting

The study used anonymised data from the Clinical Practice Research Datalink (CPRD), comprising a representative sample of routinely collected primary care data in England between 2013 and 2017 and and linked Hospital Episode Statistics data.

Participants

168 767 individuals age-eligible for varicella zoster vaccination registered at a general practice in England contributing data to CPRD.

Main outcome measures

Electronic health records indicating immunosuppression, zoster vaccination, diagnoses of specific varicella-zoster virus (VZV)-related disease and non-specific

SUBMITTER: Grint DJ 

PROVIDER: S-EPMC7045073 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature