Risks of developing ulcerative colitis and Crohn's disease in relation to silica dust exposure in Sweden: a case-control study.

ABSTRACT:

Objective

To determine whether occupational exposure to silica dust causes an increased risk of developing Crohn's disease (CD) and ulcerative colitis (UC).

Design

Case-control study of CD (K50) and UC (K51) from 2007 through 2016. Controls were matched to cases (2:1) based on age, sex and county at the time of diagnosis. A job exposure matrix was used to estimate the occupational silica exposure of all cases and controls.

Setting

Medical and occupational data from the National Outpatient Register were used to implement a case-control analysis, while the two controls used for each case were selected from the National Register of the Total Population.

Participants

All men and women aged 20-65 years old who were diagnosed with CD (K50) and UC (K51) during the yea

SUBMITTER: Wallden A 

PROVIDER: S-EPMC7045158 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature