Randomised controlled trial to investigate the relationship between mild hypercapnia and cerebral oxygen saturation in patients undergoing major surgery.

ABSTRACT:

Objectives

The effects of hypercapnia on regional cerebral oxygen saturation (rSO₂) during surgery are unclear. We conducted a randomised controlled trial to investigate the relationship between mild hypercapnia and rSO₂. We hypothesised that, compared with targeted normocapnia (TN), targeted mild hypercapnia (TMH) during major surgery would increase rSO₂.

Design

A prospective, randomised, controlled trial in adult participants undergoing elective major surgery.

Setting

A single tertiary centre in Heidelberg, Victoria, Australia.

Participants

40 participants were randomised to either a TMH or TN group (20 to each).

Interventions

TMH (partial pressure of carbon dioxide in arterial blood, PaCO₂, 45-55 mm Hg) or T

SUBMITTER: Wong C 

PROVIDER: S-EPMC7045198 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature