Accumulation of succinate controls activation of adipose tissue thermogenesis.

ABSTRACT: Thermogenesis by brown and beige adipose tissue, which requires activation by external stimuli, can counter metabolic disease¹. Thermogenic respiration is initiated by adipocyte lipolysis through cyclic AMP-protein kinase A signalling; this pathway has been subject to longstanding clinical investigation^2-4. Here we apply a comparative metabolomics approach and identify an independent metabolic pathway that controls acute activation of adipose tissue thermogenesis in vivo. We show that substantial and selective accumulation of the tricarboxylic acid cycle intermediate succinate is a metabolic signature of adipose tissue thermogenesis upon activation by exposure to cold. Succinate accumulation occurs independently of adrenergic signalling, and is sufficient to elevate t

SUBMITTER: Mills EL 

PROVIDER: S-EPMC7045287 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature