Opposing Regulation of Cocaine Seeking by Glutamate and GABA Neurons in the Ventral Pallidum.

ABSTRACT: Projections from the nucleus accumbens to the ventral pallidum (VP) regulate relapse in animal models of addiction. The VP contains GABAergic (VP_GABA) and glutamatergic (VP_Glu) neurons, and a subpopulation of GABAergic neurons co-express enkephalin (VP_Penk). Rabies tracing reveals that VP_Glu and VP_Penk neurons receive preferential innervation from upstream D1- relative to D2-expressing accumbens neurons. Chemogenetic stimulation of VP_Glu neurons inhibits, whereas stimulation of VP_GABA and VP_Penk neurons potentiates cocaine seeking in mice withdrawn from intravenous cocaine self-administration. Calcium imaging reveals cell type-specific activity patterns when animals learn to suppress drug seeking during

SUBMITTER: Heinsbroek JA 

PROVIDER: S-EPMC7045305 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature