Evaluation of Second-Generation Lipophosphonoxins as Antimicrobial Additives in Bone Cement.

ABSTRACT: Successful surgeries involving orthopedic implants depend on the avoidance of biofilm development on the implant surface during the early postoperative period. Here, we investigate the potential of novel antibacterial compounds-second-generation lipophosphonoxins (LPPOs II)-as additives to surgical bone cements. We demonstrate (i) excellent thermostability of LPPOs II, which is essential to withstand elevated temperatures during exothermic cement polymerization; (ii) unchanged tensile strength and elongation at the break properties of the composite cements containing LPPOs II compared to cements without additives; (iii) convenient elution kinetics on the order of days; and (iv) the strong antibiofilm activity of the LPPO II-loaded cements even against bacteria resistant to the medicinally

SUBMITTER: Zbornikova E 

PROVIDER: S-EPMC7045315 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature