Agglomeration of titanium dioxide nanoparticles increases toxicological responses in vitro and in vivo.

ABSTRACT:

Background

The terms agglomerates and aggregates are frequently used in the regulatory definition(s) of nanomaterials (NMs) and hence attract attention in view of their potential influence on health effects. However, the influence of nanoparticle (NP) agglomeration and aggregation on toxicity is poorly understood although it is strongly believed that smaller the size of the NPs greater the toxicity. A toxicologically relevant definition of NMs is therefore not yet available, which affects not only the risk assessment process but also hinders the regulation of nano-products. In this study, we assessed the influence of NP agglomeration on their toxicity/biological responses in vitro and in vivo.

Results

We tested two TiO₂ NPs with different primary sizes (17 and 117

SUBMITTER: Murugadoss S 

PROVIDER: S-EPMC7045370 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature