Fecal Viral Community Responses to High-Fat Diet in Mice.

ABSTRACT: Alterations in diet can have significant impact on the host, with high-fat diet (HFD) leading to obesity, diabetes, and inflammation of the gut. Although membership and abundances in gut bacterial communities are strongly influenced by diet, substantially less is known about how viral communities respond to dietary changes. Examining fecal contents of mice as the mice were transitioned from normal chow to HFD, we found significant changes in the relative abundances and the diversity in the gut of bacteria and their viruses. Alpha diversity of the bacterial community was significantly diminished in response to the diet change but did not change significantly in the viral community. However, the diet shift significantly impacted the beta diversity in both the bacterial and viral communities.

SUBMITTER: Schulfer A 

PROVIDER: S-EPMC7045389 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature