Natural biased signaling of hydroxycarboxylic acid receptor 3 and G protein-coupled receptor 84.

ABSTRACT:

Background

Medium-chain fatty acids and their 3-hydroxy derivatives are metabolites endogenously produced in humans, food-derived or originating from bacteria. They activate G protein-coupled receptors, including GPR84 and HCA₃, which regulate metabolism and immune functions. Although both receptors are coupled to G_i proteins, share at least one agonist and show overlapping tissue expression, GPR84 exerts pro-inflammatory effects whereas HCA₃ is involved in anti-inflammatory responses. Here, we analyzed signaling kinetics of both HCA₃ and GPR84, to unravel signal transduction components that may explain their physiological differences.

Methods

To study the signaling kinetics and components involved in signal transduction of both re

SUBMITTER: Peters A 

PROVIDER: S-EPMC7045412 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature