Manipulation of macrophage polarization by peptide-coated gold nanoparticles and its protective effects on acute lung injury.

ABSTRACT: BACKGROUND:Macrophage polarization and reprogramming in the lung play a critical role in the initiation, development and progression of acute lung injury (ALI). Regulating the activation and differentiation of pulmonary macrophages may provide a potential therapeutic strategy to treat ALI. We previously developed a novel class of anti-inflammatory nanoparticles (P12) that can potently inhibit Toll-like receptor (TLR) signaling in macrophages. These bioactive nanodevices were made of gold nanoparticles (GNPs) coated with hexapeptides to not only ensure their physiological stability but also enable GNPs with TLR inhibitory activity. RESULTS:In this study, using a lipopolysaccharide (LPS) induced ALI mouse model, we showed that P12 was able to alleviate lung inflammation and damage through re

SUBMITTER: Wang L 

PROVIDER: S-EPMC7045427 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature