Identification of differentially expressed miRNAs in differentiating benign from malignant pleural effusion.

ABSTRACT:

Background

Tuberculosis pleural effusion (TPE) and malignant pleural effusion (MPE) are very common clinical complications. Considering the totally different prognosis and clinical treatment of TPE and MPE, the accurate and non-invasive diagnosis are very critical for patients with pleural effusion to initiate efficient management and treatment. However, effective clinical biomarkers were rarely explored to distinguish benign from MPE. The purpose of this study is to identify potential miRNAs which can probably be used to differentiate malignant pleural effusion from TPE.

Results

A total of 23 significantly differentially expressed miRNAs were identified in MPE, with 18 up-expressed and 5 down-expressed. And the target genes of the miRNAs mainly involved in the biology proce

SUBMITTER: Bao Q 

PROVIDER: S-EPMC7045593 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature