Unusual sequence characteristics of human chromosome 19 are conserved across 11 nonhuman primates.

ABSTRACT: BACKGROUND:Human chromosome 19 has many unique characteristics including gene density more than double the genome-wide average and 20 large tandemly clustered gene families. It also has the highest GC content of any chromosome, especially outside gene clusters. The high GC content and concomitant high content of hypermutable CpG sites raises the possibility chromosome 19 exhibits higher levels of nucleotide diversity both within and between species, and may possess greater variation in DNA methylation that regulates gene expression. RESULTS:We examined GC and CpG content of chromosome 19 orthologs across representatives of the primate order. In all 12 primate species with suitable genome assemblies, chromosome 19 orthologs have the highest GC content of any chromosome. CpG dinucleotides an

SUBMITTER: Harris RA 

PROVIDER: S-EPMC7045612 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature