SERPINA1 gene identified in RNA-Seq showed strong association with milk protein concentration in Chinese Holstein cows.

ABSTRACT: The detection of candidate genes and mutations associated with phenotypic traits is important for livestock animals. A previous RNA-Seq study revealed that SERPINA1 gene was a functional candidate that may affect milk protein concentration in dairy cows. To further confirm the genetic effect of SERPINA1 on milk protein traits, genetic polymorphisms were identified and genotype-phenotype associations were performed in a large Chinese Holstein cattle population. The entire coding region and the 5'-regulatory region (5'-UTR) of SERPINA1 was sequenced using pooled DNA of 17 unrelated sires. Association studies for five milk production traits were performed using a mixed model with a population encompassing 1,027 Chinese Holstein cows. A total of four SNPs were identified i

SUBMITTER: Li C 

PROVIDER: S-EPMC7045893 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature