Maternal Exposure to Environmental Disruptors and Sexually Dimorphic Changes in Maternal and Neonatal Oxidative Stress.

ABSTRACT: Early pregnancy exposure to endocrine disrupting chemicals (EDCs) may contribute to poor birth outcomes through oxidative stress (OS)-mediated disruption of the maternal and fetal milieu. Most studies have investigated the effect of single EDC exposures on OS. Assess the association of uniquely weighted mixtures of early pregnancy exposures with the maternal and neonatal OS markers. Prospective analysis of mother-infant dyads. University hospital. 56 mother-infant dyads. The association of OS markers (nitrotyrosine, dityrosine, chlorotyrosine) in maternal first trimester and term, and cord blood plasma with maternal first trimester exposure levels of each of 41 toxicants (trace elements, metals, phenols, and phthalates) from 56 subjects was analyzed using Spearman correlations and linear r

SUBMITTER: Puttabyatappa M 

PROVIDER: S-EPMC7046018 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature